Publications by authors named "P Vijayanand"
Article Synopsis
- Researchers developed a new high-throughput method to analyze the transcriptomes of immune cell complexes without needing complex data processing, focusing on T cells and monocytes during active infections.
- The study revealed distinct gene expression patterns in T cells and monocytes in blood samples from patients with active tuberculosis (TB) and dengue, highlighting their immune interactions.
- Findings indicated that T cells in these complexes displayed characteristics of active immune responses, including effector cell traits and RNA exchange with monocytes, which suggests a deeper understanding of immune interactions during infections.
Background: Tele-neurorehabilitation (TNR) allows for remote delivery of rehabilitation services for those with neurological disabilities. Despite growing global interest and uptake, its adoption remains challenging in Low-and-Middle-Income-Countries (LMICs).
Objective: To explore available literature on the nature of training and education, research and practice of TNR in LMICs.
E-cigarette vapor extract alters human eosinophil gene expression in an effect mediated by propylene glycol, glycerin, and nicotine.
J Leukoc Biol
November 2024
E-cigarette use has become widespread, and its effects on airway inflammation and disease are not fully delineated. E-cigarette vapor extract (EVE) profoundly affects neutrophil function. We hypothesized that EVE also alters eosinophil function and thus could impact allergic airway disease.
View Article and Find Full Text PDFTo understand the role of T cells in the pathogenesis of ulcerative colitis (UC), we analyzed colonic T cells isolated from patients with UC and controls. Here we identified colonic CD4 and CD8 T lymphocyte subsets with gene expression profiles resembling stem-like progenitors, previously reported in several mouse models of autoimmune disease. Stem-like T cells were increased in inflamed areas compared to non-inflamed regions from the same patients.
View Article and Find Full Text PDFArticle Synopsis
- Researchers studied how genetic variation affects vaccine responses in infants from African countries, finding specific HLA associations with antibody responses to vaccines like pertussis and hepatitis B.
- They used genetic data from over 1,700 individuals to identify patterns in HLA types that could explain up to 10% of the response variability in infants to these vaccines.
- The study highlighted differences in immune responses based on ancestry, indicating that understanding HLA-DRB1 expression could help refine vaccine design for better effectiveness in diverse populations.