Publications by authors named "P Verwaerde"
Case Series Summary: This case series describes seven cats that were treated with high-flow nasal cannula oxygen therapy (HFNOT). Seven cats were prospectively (n = 5) or retrospectively (n = 2) included from three veterinary university referral centers between March 2020 and September 2023. Data on signalment, medical history, clinical and diagnostic findings, treatment administered, response to HFNOT and outcomes were recorded.
View Article and Find Full Text PDFThe canine diaphragm is a muscular and tendinous dome-like plate and is largely involved in digestive and respiratory functions. Very few studies compared morphology of the diaphragm between dogs and cats and no studies have investigated the effects of individual factors on this morphology. So the aim of this study was to (1) study the effects of individual factors on the morphology of the diaphragm and (2) to compare its morphology between cats and dogs.
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- Alzheimer's disease (AD) and progressive supranuclear palsy (PSP) are neurodegenerative diseases characterized by tau pathology, where AD leads to cognitive decline and PSP affects movement and balance; Progranulin (PGRN) is relevant to both conditions and can be targeted by AZP2006, a synthetic compound aimed at stabilizing PGRN and reducing tau aggregation.
- A phase 1 clinical study evaluated AZP2006's safety, tolerability, and pharmacokinetics involving healthy male volunteers receiving various doses; no severe adverse events occurred, and any minor side effects were temporary.
- AZP2006 was quickly absorbed and had a favorable safety profile, but elevated levels of its M2 metabolite require further
Background: Mechanical circulatory supports are used in case of cardiogenic shock (CS) refractory to conventional therapy. Several devices can be employed, but are limited by their availability, benefit risk-ratio, and/or cost.
Aims: To investigate the feasibility, safety, and effectiveness of a long-term support by a new available device (IVAC2L) in pigs.
Dexmedetomidine and acepromazine, sedatives commonly used in dogs have opposite vascular effects, resulting in afterload increase and decrease, respectively. This could variably affect systolic myocardial function. Previous echocardiographic studies assessing the cardiovascular effects of these drugs used conventional echocardiography, while advanced techniques such as speckle tracking echocardiography (STE) and tissue Doppler imaging (TDI), which are known to provide a more accurate assessment of systolic function, have been rarely used for this aim.
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