Publications by authors named "P Vermeulen"

This scoping review aimed to map the various facets of intuition in occupational therapy (OT), from its definitions, theoretical frameworks, epistemological paradigms to practical applications, highlighting its role in decision-making. Following the Joanna Briggs Institute methodology, a systematic search of five databases from 1990 to August 2023 identified 337 records related to OT and intuition. After removing duplicates and applying eligibility criteria, 22 studies were included.

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Article Synopsis
  • Metastatic behavior in liver-metastatic colorectal cancer (CRC) varies significantly based on histopathological growth patterns (HGPs), influencing treatment outcomes, with desmoplastic HGP being linked to favorable and replacement HGP to unfavorable outcomes.
  • Understanding cellular and molecular factors of these growth patterns is crucial for improving cancer biology knowledge and designing effective clinical trials.
  • Analysis of tumor tissue reveals that HGPs are influenced by epigenetic factors rather than specific gene mutations, with distinct gene expression differences reflecting cancer biology themes, such as inflammation for desmoplastic and cell proliferation for replacement patterns.
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Background: Histopathological growth patterns are one of the strongest prognostic factors in patients with resected colorectal liver metastases. Development of an efficient, objective and ideally automated histopathological growth pattern scoring method can substantially help the implementation of histopathological growth pattern assessment in daily practice and research. This study aimed to develop and validate a deep-learning algorithm, namely neural image compression, to distinguish desmoplastic from non-desmoplastic histopathological growth patterns of colorectal liver metastases based on digital haematoxylin and eosin-stained slides.

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Rationale: Practice context is known to influence the deployment of competencies. The COVID-19 pandemic created a major disruption in many practice contexts. The objective was to understand the lived experience of rehabilitation clinicians during a major disruption of their practice context, namely, the COVID-19 pandemic.

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