Publications by authors named "P Verhezen"
Heterophilic antibodies leading to falsely positive D-dimer concentration in an adolescent.
Res Pract Thromb Haemost
January 2023
Background: We present the case of a 15-year-old adolescent with suspected pulmonary embolism and repeatedly elevated D-dimer levels.
Key Clinical Question: We aim to determine the cause for elevated D-dimer levels in a patient without venous thromboembolism.
Clinical Approach: When the D-dimer measurement was repeated with different assays, D-dimer levels were within the normal reference interval.
Article Synopsis
- The diagnostic evaluation for bleeding patients traditionally follows a stepwise process, which can be inefficient and burdensome for patients.
- A comparison of a conventional stepwise approach versus a proposed all-in-one diagnostic method showed that the all-in-one approach identified more patients with bleeding disorders (19 additional diagnoses) and reduced patient burden.
- However, this improved diagnostic strategy comes at a higher cost per patient (€359), raising questions about the justification of these expenses for diagnosing bleeding disorders effectively.
Introduction: Valproic acid (VPA) is a frequently prescribed anti-epileptic drug. Since its introduction side effects on hemostasis are reported. However, studies show conflicting results, and the clinical relevance is questioned.
View Article and Find Full Text PDFPatients using antithrombotic drugs after percutaneous coronary intervention (PCI) are at risk for bleeding and recurrent ischemia. We aimed to explore routine and tissue plasminogen activated (tPA) ROTEM results in a post-PCI population on dual antithrombotic treatment. In this prospective cohort, 440 patients treated with double antithrombotic therapy after recent PCI and with ≥3 risk factors for either ischemic or bleeding complications were included and compared with a control group ( = 95) consisting of perioperative patients not using antithrombotic medication.
View Article and Find Full Text PDFPatients referred for evaluation of bleeding symptoms occasionally have a prolonged platelet function analyser (PFA) closure time, without evidence for von Willebrand disease or impaired platelet aggregation. The aim of this study was to establish a shear-dependent platelet function defect in these patients. Patients were included based on high bleeding score and prior PFA prolongation.
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