Potentials of cytokinesis blocked micronucleus assay in radiation triage and biological dosimetry.

The measurement of micronucleus (MN) in the cytokinesis-block arrested binucleated cells has been extensively used as a biomarker in many radiation biology applications in specific biodosimetry. Following radiation casualties, medical management of exposed individuals begins with triage and biological dosimetry. The cytokinesis blocked micronucleus (CBMN) assay is the alternate for the gold standard dicentric chromosome assay in radiation dose assessment.

High-efficiency broadband out-of-plane fiber-to-polymer waveguide grating coupler.

Polymer photonics is receiving significant attention due to its potential for a wide range of integrated photonic applications and wide wavelength transparency. Wafer-scale testing is challenging due to low-index contrast in polymer waveguides. In this Letter, we demonstrate an amorphous silicon based out-of-plane polymer waveguide grating coupler.

Reviewing the audacity of elixirs of inflammatory bowel disease from mushroom β-glucans: The solved and unresolved.

Background: Mushrooms are known as the elixirs of life, they are packed with various bioactive compounds that make them not only tasty but also healthy. Thus, they not just fall within the category of nutritional foods, but also functional foods. When medicinal bioactive components are sought after from every other available resource, these natural reservoirs are easily accessible therapeutic sources.

Ataxia Telengectesia Protein Influences Bleomycin-Induced DNA Damage in Human Fibroblast Cells.

Human cancer is caused mainly by exposure to genotoxic chemicals; therefore, cellular defence mechanisms against genotoxic stress are crucial. Genetic factors are essential to maintaining genome stability and play a vital role in overcoming this by repairing the genome damage caused by any agent in order to prevent chromosomal instability. To examine the influence of the genetic makeup in specific ataxia-telangiectasia (ATM), we have examined non-cancerous fibroblast cell lines (HLF, AG1522 and L6) and cells with ATM mutated deficiency (GM4405).