A novel HLA-A null allele (A*02:395N) with stop codon in exon 2 generated by single nucleotide exchange.

The new HLA-A*02:395N allele differs from A*02:01:01 at one nucleotide position in the exon 2.

Detection of A B acute lymphoblastic leukaemia blast-specific mutation in HLA-B*39:01.

Human leucocyte antigen (HLA) modifications observed in blast cells in haematologic malignancies can play an important role in disease progression and its therapy. Here we describe an insertion/deletion mutation in the second exon of HLA-B*39:01 that occurred in the blast cells of a patient with B-ALL. This mutation was not present in the nonleukemic cells, in which HLA-B*39:01 was normally expressed.

Distribution of KIR genes in the population of unrelated individuals homozygous for ancestral haplotype AH8.1 (HLA-A1B8DR3).

Despite the independent segregation of genes encoding killer immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA), there is some evidence of some kind of co-evolution. Therefore, one could expect reduced KIR diversity within the HLA restricted population. A total of 41 unrelated individuals homozygous for ancestral HLA haplotype AH8.

Identification of a novel HLA-DRB1*14 allele, HLA-DRB1*1458, by sequence-based typing.

Identification of a novel HLA-DRB1*1458 allele within a Caucasian individual using sequence-based typing.