Publications by authors named "P Velez"
Article Synopsis
- Hydroxyurea (HU) is the primary treatment for essential thrombocythemia (ET), but there are no clear guidelines for when to switch therapies.
- In a study of 1080 patients, 67% achieved a complete hematological response (CHR) after five years, with high-risk patients showing lower risks of arterial thrombosis if they achieved CHR.
- Patients with HU resistance or intolerance had a higher chance of developing myelofibrosis, but this did not significantly impact overall survival or thrombotic risk; CHR is linked to improved outcomes and may guide future treatment decisions.
Article Synopsis
- Aflatoxin B (AFB) and fumonisin B (FB) are harmful mycotoxins found in cereals that can increase the risk of liver cancer, yet their combined effects have not been extensively researched.
- This study investigated how different concentrations of AFB and FB, as well as their mixtures, impact the differentiation of immune cells in mouse spleen, focusing on regulatory T cells (Treg) and Th17 cells, and the role of the aryl hydrocarbon receptor (Ahr) in this process.
- The results showed that AFB and AFB-FB mixtures influence immune cell differentiation and immunotoxicity through Ahr signaling, potentially enhancing the risk of immune suppression and contributing to tumor growth evasion when these
Salmonellosis, caused by serovar Typhimurium, is a significant global threat. Host immunity limits bacterial replication by inducing hepcidin, which degrades ferroportin, reducing iron transfer. However, this boosts macrophage iron storage, aiding intracellular pathogens like .
View Article and Find Full Text PDFOxygen minimum zones (OMZ) represent ~8% of the ocean, with the Pacific as the largest and top expanding area. These regions influence marine ecosystems, promoting anaerobic microbial communities. Nevertheless, only a fraction of microbial diversity has been studied, with fungi being the less explored component.
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