Publications by authors named "P Vart"

Importance: Chronic kidney disease (CKD) is a global health priority affecting almost 1 billion people. New therapeutic options and clinical trial innovations such as adaptive platform trials provide an opportunity to efficiently test combination therapies.

Objective: To describe the design and baseline results of the Global Kidney Patient Trials Network (GKPTN) and the design and structure of the global adaptive platform clinical trial Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect (CAPTIVATE) to find new therapeutic options and treatments for people with kidney disease.

View Article and Find Full Text PDF

Background: Alemtuzumab can be an alternative to rabbit anti-thymocyte globulin (rATG) to treat severe or glucocorticoid-resistant acute T cell-mediated kidney transplant rejection (TCMR). Yet, there are few reports in which these two treatments are evaluated let alone, compared. This study describes the real-world clinical experience of both therapies and compares their efficacy and toxicity.

View Article and Find Full Text PDF
Article Synopsis
  • Albuminuria is a significant marker for kidney and cardiovascular problems in chronic kidney disease (CKD), and this study analyzed its impact on health outcomes in CKD patients receiving dapagliflozin or placebo.
  • A post-hoc analysis of the DAPA-CKD trial involved 4,304 patients and found that dapagliflozin significantly decreased urinary albumin-to-creatinine ratio (UACR) after four months, with a 36% reduction in those with diabetes and 21% in those without.
  • The study concluded that greater reductions in albuminuria were linked to lower risks of serious kidney and cardiovascular events, providing evidence for the benefits of dapagliflozin in managing CKD.
View Article and Find Full Text PDF

Background: Higher temperatures are associated with higher rates of hospital admissions for nephrolithiasis and acute kidney injury. Occupational heat stress is also a risk factor for kidney dysfunction in resource-poor settings. It is unclear whether ambient heat exposure is associated with loss of kidney function in patients with established chronic kidney disease.

View Article and Find Full Text PDF