Publications by authors named "P Vanelle"
Enterovirus (EV) is a genus that includes a large diversity of viruses spread around the world. They are the main cause of numerous diseases with seasonal clusters, like hand-foot-mouth disease (HFMD). A vaccine is marketed in China for the prevention of HFMD caused by EV-A71.
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- - Leishmaniasis, caused by a protozoan, has treatment gaps, leading to the development of new amidoxime derivatives aimed at improving antileishmanial activity.
- - Twelve new compounds were created by modifying a previous hit, using a three-step synthesis process that included cyclization, amidation, and reaction with hydroxylamine.
- - Three specific derivatives showed promising in vitro toxicity-activity results, with high selectivity indices (SI) against the parasite, indicating they could potentially be more effective and less toxic than existing treatments like Pentamidine.
In the quest for powerful, safe, and storable photoinduced-electron transfer (PET) donors, the attention is turned to the α-trihalomethylated amine moiety that is not studied in the context of PET-reductants. The thermal and photophysical properties of α-trifluoromethylated quinolines are thus studied and their reducing abilities evaluated as initiators of polymerization reactions. Polymers of high molecular weights are obtained through a radical polymerization process and the PET-donor can be stored within the monomer for several months without losing its efficiency.
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- The study focuses on creating new oral antileishmanial compounds by synthesizing 4,5-dihydrofuran derivatives with an amidoxime group.
- A previously identified compound showed effective inhibition against Leishmania parasites, prompting researchers to modify the structure by substituting an aliphatic group at position 3 of the ring.
- The synthesis utilized microwave-assisted oxidation methods, leading to aliphatic derivatives that demonstrated promising biological activity, particularly against the amastigote form of Leishmania.
Article Synopsis
- * The multi-target directed ligand (MTDL) strategy is proposed as a new approach to develop effective antiviral drugs by synthesizing compounds that can target multiple pathways of the virus.
- * This study reviews previous clinical trials to identify promising antiviral candidates, suggesting that using MTDL could enhance drug efficacy, broaden treatment options, and potentially reduce side effects and the risk of drug resistance.