Publications by authors named "P Van Schil"
Introduction: The EORTC-Lung Cancer Group initiated a Delphi consensus process to establish a consensual definition of resectable stage III non-small cell lung cancer (NSCLC) for the use in clinical trials, including a systematic review, survey, and review of clinical cases. Here, the survey results are presented, aimed to identify areas of controversy.
Methods: A survey was distributed among the members of six international organizations related to lung cancer.
Objective: The study aimed to assess the opinion of pathologists and thoracic surgeons of the International Association for the Study of Lung Cancer (IASLC) regarding application and interpretation of the residual tumor (R) classification for lung cancer.
Methods: Based on their membership-profile a total of n=623 pathologists and thoracic surgeons were identified and contacted by email with a cover letter and a link to an online survey. The questionnaire consisted of 12 questions about various aspects on application and interpretation of the R classification for lung cancer.
Article Synopsis
- Pleural mesothelioma (PM) is a rare and aggressive cancer often diagnosed late, highlighting the need for early detection biomarkers through DNA methylation analysis.
- This study generated a large dataset comparing DNA methylation patterns between healthy pleura and PM, identifying over 81,000 differentially methylated sites, including five key sites linked to specific genes.
- The findings indicate that PM has unique methylation profiles that distinguish it from other lung diseases and may aid in understanding the disease’s progression and offer potential for biomarker development.
Background: Pulmonary nodules are small, focal lesions often identified via computed tomography (CT) scans. Although the majority are benign, a small percentage of them may be malignant or potentially become malignant, underscoring the importance of early detection and effective management. This study systematically reviews the epidemiology, risk factors, and management strategies for pulmonary nodules, comparing findings across Chinese and non-Chinese populations to better inform the actuarial calculations for predicting the demand of medical services for patients with pulmonary nodules.
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