Investigating the effect of template head models on Event-Related Potential source localization: a simulation and real-data study.

Introduction: Event-Related Potentials (ERPs) are valuable for studying brain activity with millisecond-level temporal resolution. While the temporal resolution of this technique is excellent, the spatial resolution is limited. Source localization aims to identify the brain regions generating the EEG data, thus increasing the spatial resolution, but its accuracy depends heavily on the head model used.

Subclinical epileptiform activity in the Alzheimer continuum: association with disease, cognition and detection method.

Background: Epileptic seizures are an established comorbidity of Alzheimer's disease (AD). Subclinical epileptiform activity (SEA) as detected by 24-h electroencephalography (EEG) or magneto-encephalography (MEG) has been reported in temporal regions of clinically diagnosed AD patients. Although epileptic activity in AD probably arises in the mesial temporal lobe, electrical activity within this region might not propagate to EEG scalp electrodes and could remain undetected by standard EEG.

Hippocampal seizures differentially modulate locus coeruleus activity and result in consistent time-locked release of noradrenaline in rat hippocampus.

The locus coeruleus (LC) is a small brainstem nucleus and is the sole source of noradrenaline in the neocortex, hippocampus and cerebellum. Noradrenaline is a powerful neuromodulator involved in the regulation of excitability and plasticity of large-scale brain networks. In this study, we performed a detailed assessment of the activity of locus coeruleus neurons and changes in noradrenergic transmission during acute hippocampal seizures evoked with perforant path stimulation, using state-of-the-art methodology.

Uncovering the underlying factors of ERP changes in the cyberball paradigm: A systematic review investigating the impact of ostracism and paradigm characteristics.

The Cyberball is the most commonly employed paradigm for the investigation of the effects of social exclusion, also called ostracism. The analysis of event-related potentials (ERPs), short-term stimulus-induced fluctuations in the EEG signal, has been employed for the identification of time-sensitive neural responses to ostracism-related information. Changes in ERPs during the Cyberball are normally attributed to the effect of ostracism, but it has been argued that characteristics of the paradigm, not ostracism, are the driving force for these changes.