Publications by authors named "P Van Duijn"
Article Synopsis
- A study analyzed the management and mortality outcomes of nontuberculous mycobacterial (NTM) infections in solid organ transplant (SOT) recipients, focusing on data from 2008 to 2018.
- Out of 85 patients with NTM infections and 169 matched controls, one-year mortality was significantly higher in the infected group (20%) compared to controls (3%), particularly among those who had lung transplants.
- Factors like time to treatment and changes in immunosuppression levels did not show a direct correlation with mortality rates among the patients.
Background: Risk factors for nontuberculous mycobacteria (NTM) infections after solid organ transplant (SOT) are not well characterized. Here we aimed to describe these factors.
Methods: Retrospective, multinational, 1:2 matched case-control study that included SOT recipients ≥12 years old diagnosed with NTM infection from 1 January 2008 to 31 December 2018.
Background: Repeated rotation of empiric antibiotic treatment strategies is hypothesized to reduce antibiotic resistance. Clinical rotation studies failed to change unit-wide prevalence of antibiotic resistant bacteria (ARB) carriage, including an international cluster-randomized crossover study. Unit-wide effects may differ from individual effects due to "ecological fallacy".
View Article and Find Full Text PDFBackground: Prostate cancer is recognized as a heterogeneous disease demanding appropriate preclinical models that reflect tumor complexity. Previously, we established the PSA-Cre;PtenLoxP/LoxP genetic engineered mouse model (GEMM) for prostate cancer reflecting the various stages of tumor development. Prostate tumors in this Pten KO model slowly develop, requiring more than 10 months.
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