Publications by authors named "P Van Crombrugge"
The androgen receptor signaling inhibitor apalutamide is used successfully for the treatment of prostate cancer. An increased risk of hypothyroidism, mostly subclinical, has been reported in the SPARTAN and TITAN trials. We present three cases of subacute deterioration of previously known but well-controlled hypothyroidism treated with levothyroxine, occurring shortly after the initiation of treatment with apalutamide, resulting in severe hypothyroidism.
View Article and Find Full Text PDFAims: To monitor fetal size and identify predictors for birthweight in women with gestational diabetes (GDM) and normal glucose tolerance (NGT).
Methods: Cohort study of 1843 women universally screened for GDM, with routine ultrasounds each trimester. Women with GDM and NGT were categorized in subgroups by birthweight centile.
Aims: To determine the impact of breastfeeding on the risk of postpartum glucose intolerance in women with gestational diabetes.
Methods: Sub-analysis of two multi-centric prospective cohort studies (BEDIP-N and MELINDA) in 1008 women with gestational diabetes. Data were collected during pregnancy and at a mean of 12 weeks postpartum.
Article Synopsis
- The study investigates the pregnancy outcomes of normal glucose tolerant (NGT) women with low glycemic levels during an oral glucose tolerance test (OGTT), focusing on various glycemia ranges.
- Researchers from Belgium analyzed data from 1,841 pregnant women to compare NGT women with low glycemia (<3.9 mmol/L) to those with higher levels, adjusting for factors like body mass index (BMI) and weight gain.
- Results show that women with glycemia below 3.9 mmol/L had better metabolic health but a significantly higher risk of having a baby with a birth weight under 2.5 kg, highlighting potential concerns for this group.
Context: More data are needed on the potential benefits and risks of gestational weight gain (GWG) less than recommended and excessive GWG in women with gestational diabetes (GDM) compared to women with normal glucose tolerance (NGT) during pregnancy.
Objective: This work aimed to evaluate association of gestational weight gain (GWG) as low, within, or above (excessive) according to Institute of Medicine (IOM) guidelines, with pregnancy outcomes in women with gestational diabetes (GDM) and normal glucose tolerance (NGT).
Methods: This prospective cohort study included 7 Belgian hospitals and 1843 women receiving universal GDM screening with a 75-g oral glucose tolerance test.