[Molecular characterization of pandemic influenza viruses A/H1N1(sw2009) isolated in Russia in 2009-2010].

Aim: Assessment of genetic diversity of influenza virus A/H1N1 (sw2009) variants circulated in Russia, study of virus' pathogenicity in humans and potential resistance to antiviral drugs.

Materials And Methods: Sequencing of PCR-fragments of genome of influenza viruses isolated from clinical and autopsy samples of 436 patients. Four full genome sequences of influenza viruses A/H1N1 (sw2009) were obtained.

[Involvement of the global regulators GrrS, RpoS, and SplIR in formation of biofilms in Serratia plymuthica].

Most bacteria exist in the natural environment as biofilms, multicellular communities attached to hard surfaces. Biofilms have a characteristic architecture and are enclosed in the exopolymer matrix. Bacterial cells in biofilms are extremely resistant to antibacterial factors.

[Influence of mutations in global regulator genes grrS and rpoS on synthesis of phosphatases in Serratia plymuthica].

The participation of global regulators GrrS (sensor kinase GacA/GacS-like regulatory system) and sigma S subunit of RNA polymerase in the control of phosphatase synthesis in a soil bacterium Serratia plymuthica was shown. In cells of null mutants for genes grrS and rpoS synthesis of low-acidic and alkaline phosphatases was markedly decreased.