Phytochemicals in Obesity Management: Mechanisms and Clinical Perspectives.

Purpose Of Review: This review explores the mechanistic pathways and clinical implications of phytochemicals in obesity management, addressing the global health crisis of obesity and the pressing need for effective, natural strategies to combat this epidemic.

Recent Findings: Phytochemicals demonstrate significant potential in obesity control through various molecular mechanisms. These include the modulation of adipogenesis, regulation of lipid metabolism, enhancement of energy expenditure, and suppression of appetite.

Pranayama (yogic breathing practices) in Parkinson's disease: protocol for a scoping review of literature.

Introduction: Parkinson's disease is a neurodegenerative disorder that presents with motor symptoms such as tremors, slowness and gait difficulties, in addition to various non-motor symptoms such as anxiety, depression and autonomic and sleep disturbances. Pranayama (yogic breathing practices) has been studied as a part of yoga interventions in Parkinson's disease. Previous systematic reviews and meta-analyses have not detailed the pranayama practices used in clinical studies, and there is no clarity on the pranayama practices that would be most beneficial for Parkinson's disease.

Molecular and phylogenetic analyses of the first complete genome sequence of Duck hepatitis A virus genotype 2 from India.

Duck viral hepatitis (DVH) caused by duck hepatitis A virus (DHAV) is a highly contagious and economically important disease of ducklings worldwide. In many parts of the globe, disease outbreaks are reported in spite of vaccinations, probably due to antigenic diversity among DHAV genotypes. We previously reported the first isolation of DHAV-2 (Genotype -2) from ducklings in Tamil Nadu, India.

Sitravatinib in combination with nivolumab plus ipilimumab in patients with advanced clear cell renal cell carcinoma: a phase 1 trial.

We conducted a phase I trial to determine the optimal dose of triplet therapy with the tyrosine kinase inhibitor sitravatinib plus nivolumab plus ipilimumab in 22 previously untreated patients with advanced clear cell renal cell carcinoma. The primary endpoint was safety. Secondary endpoints were objective response rate (ORR), disease control rate (DCR), duration of response (DOR), progression-free survival (PFS), overall survival (OS), 1-year survival probability, and sitravatinib pharmacokinetics.

Exploring the correlations between social support, resilience, well-being, and mental health variables among youth in border areas of Jammu and Kashmir.

Background: The border areas of Jammu and Kashmir have long been affected by conflict, potentially impacting the mental health of youth. Understanding the relationships between social health factors and mental health outcomes in these regions is crucial for developing effective interventions.

Aim: This study aims to investigate the correlations between social health factors (social support, resilience, and well-being) and mental health outcomes (stress, anxiety, and depression) among youth living in the border areas of Jammu and Kashmir.