Phytochemical and Antioxidant Analysis of Bioactive Compound Extract from Nelumbo nucifera against Cancer Proteins: In Silico Spectroscopic Approach.

Nelumbo nucifera, an aquatic crop cultivated throughout Asian countries, belongs to the Nelumbonaceae family and has been widely used in traditional medicines with key pharmacological activities such as anti-viral, antipyretic, antioxidant, anti-steroid, anti-inflammatory, anti-arrhythmia, anti-obesity, and anti-aging properties. The present study aims to explore and assess the phytochemical composition, GC-MS profiling, antioxidant efficacy, and the major phytoconstituent phytol subjected to theoretical spectroscopic characterization using the DFT method. The phytochemical profiling of N.

Biomarkers.

Background: Mild cognitive impairment(MCI) is characterized by an impairment in one or more cognitive domains greater than expected for a person's age and educational background with preserved functional independence. Functional Near Infra-Red Spectroscopy (fNIRS) is a modality of non-invasive neuroimaging that utilizes the optical properties of oxygenated and deoxygenated hemoglobin in the tissue to measure their absolute or relative concentrations following neuronal activity. fNIRS has been used to evaluate neurohemodynamics in MCI.

Developing Topics.

Background: Dementia care is incomplete without active caregiver involvement. Yet, existing cognitive interventions often overlook this crucial aspect. This study aims to develop and evaluate the feasibility of a Caregiver Driven Cognitive Training (CDCT) program in the Indian context, recognizing caregivers as essential partners in the care process.

Alzheimer's Imaging Consortium.

Background: We present the results of a task-based fMRI study in early Alzheimer's disease(mild cognitive impairment, MCI and mild Alzheimer's disease, AD) using a novel-fMRI memory paradigm suitable for use in patients with significant cognitive impairment having difficulties with remembering complex instructions.

Method: The study samples comprised 65 patients with early AD(MCI n = 42; 21 males; mild AD n = 23; 16 males) and 26(14 males) elderly cognitively healthy control(eCHC) participants. The incidental encoding phase of the paradigm(7 minutes) comprised 110 trials of common objects(55 living and 55 non-living trials which included 4 objects repeated 6 times each and 1 object repeated 5 times) while the intentional retrieval phase of the paradigm(7 minutes) comprised 55 trials of the 5 objects encoded during the previous phase(repeated 11 times each), and 55 new objects.

Dementia Care Practice.

The population of older adults in India is projected to increase from the current estimate of 150 million to 350 million by the year 2050. The prevalence of older adults with mental health problems including dementia is also increasing rapidly. The socio-cultural changes in the joint family system have necessitated the increasing requirement of formal caregivers for supporting the care of older adults in home as well as residential care institutions.