Activated Carbon-Enriched Electrospun-Produced Scaffolds for Drug Delivery/Release in Biological Systems.

To vectorize drug delivery from electrospun-produced scaffolds, we introduce a thin outer drug retention layer produced by electrospinning from activated carbon nanoparticles (ACNs)-enriched polycaprolacton (PCL) suspension. Homogeneous or coaxial fibers filled with ACNs were produced by electrospinning from different PCL-based suspensions. Stable ACN suspensions were selected by sorting through solvents, stabilizers and auxiliary components.

[Features of surgical treatment of renal cysts depending on the risk of malignancy].

Background: According to national and foreign publications, renal cyst is one of the most common urological diseases with a prevalence up to 20-50%.

Aim: To determine the results of surgical treatment of patients with renal cysts, depending on the risk of malignancy.

Materials And Methods: The analysis of 124 patients with symptomatic renal cysts who were treated in the Department of Urology of Regional Clinical Hospital was carried out.

Activated Carbon for Drug Delivery from Composite Biomaterials: The Effect of Grinding on Sirolimus Binding and Release.

Activated carbon (AC) could be potentially useful as a drug carrier in fiber polymer scaffolds destined for prolonged drug delivery. To be introduced, AC must be ground into smaller-sized particles to be introduced in scaffolds, as most biocompatible scaffolds consist of fibers with a diameter of less than 1 µm. In this study, the adsorption of sirolimus (SRL) from phosphate-buffered saline (PBS) solution and blood plasma (BP) onto AC of AX-21 type, as well as the release of SRL from AC depending on its fragmentation, were studied.

[An influence of colloidal solution of copper nanoparticles on cardiac performance and hemodynamic indices in rabbits].

Statistically significant changes in indeces of cardiac and system hemodynamics have been revealed after an intravenous injection of colloidal solution of copper nanoparticles in an acute experiment on rabbits.

The prospects of medical application of metal-based nanoparticles and nanomaterials.

Current studies, dedicated to metallic (gold, silver, iron, and copper) nanomaterials are reviewed in this paper. This metals own unique physical and chemical properties which determine their application. The medical application of metallic nanomaterials includes therapy and prophylaxis of diseases, development of new drugs and improvement of conventional ones, nanodiagnostics.