Publications by authors named "P V Pawar"
Mycosis fungoides (MF) is a neoplasm of the immune system. It is a cutaneous lymphoma originating in the peripheral epidermotropic T-cells, specifically the memory T-cells (CD45RO+). The etiology of MF is indefinite, but various factors, such as genetic and epigenetic abnormalities, environmental and occupational exposure to chemicals, infections, and cytokines (interleukin [IL]-2, IL-4, etc.
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- Butylated Hydroxytoluene (BHT), commonly used as an antioxidant in food, causes cellular toxicity by inducing oxidative stress and increasing reactive oxygen and nitrogen species (ROS and RNS).
- The herbal compounds Boeravinone B (BB) and Chebulinic acid (CA), when combined, showed significant protective effects against BHT’s toxicity by reducing levels of ROS and RNS, as well as decreasing enzymes and markers associated with oxidative stress.
- The treatment with BB and CA effectively reduced apoptosis and autophagy in cells exposed to BHT, promoting cell growth and suggesting their potential use as therapeutic agents for conditions related to oxidative stress-induced liver damage.
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- Glucuronoxylan, primarily found in dicot secondary cell walls, stabilizes plant structure through interaction with cellulose; its O-acetylation is key for maintaining this stability.
- The enzyme ESKIMO1/TBL29 acts as the primary xylan O-acetyl transferase in Arabidopsis stems, and its absence leads to stunted growth and structural issues in xylem vessels.
- Analysis of the eskimo1 mutant revealed changes in the expression of genes related to aliphatic glucosinolates (GSLs), with increased levels of certain GSLs and metabolites, indicating metabolic reprogramming tied to the plant's growth issues.
Charcot neuroarthropathy (CN) is a chronic progressive debilitating disease affecting joints, bone and soft tissue of an insensate limb, usually seen in patients with diabetes. CN of the great toe is rare or it may be associated with CN of other joints. Only a few cases have been reported on the CN of the great toe.
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