TACSTD2 in gelatinous drop-like corneal dystrophy: variant functional analysis and expression in the cornea after limbal stem cell transplantation.

Gelatinous drop-like corneal dystrophy (GDLD) is a rare autosomal recessive eye disease. GDLD is characterized by the loss of barrier function in corneal epithelial cells (CECs) and amyloid deposition due to pathogenic variants in the TACSTD2 gene. Limbal stem cell transplantation (LSCT) has been suggested as an effective therapeutic alternative for patients with GDLD.

[Intracorneal selective stromal transplantation].

Unlabelled: Deep anterior lamellar keratoplasty or penetrating keratoplasty are currently considered the optimal methods of surgical treatment of stromal dystrophies and corneal degeneration. Despite certain advantages and benefits of these methods, they also have significant limitations: involvement of superficial corneal layers in the surgery, need for suturing, development of post-keratoplasty astigmatism etc.

Purpose: This study aimed to test and describe the new method of closed sutureless keratoplasty (intracorneal selective stromal transplantation), which was indicated in isolated dystrophic and degenerative pathology of the stroma.

[Descemet membrane endothelial keratoplasty after implantation of glaucoma drainage devices].

Unlabelled: Secondary decompensation of corneal endothelium, including transplanted, is a frequent long-term complication of glaucoma drainage surgery. According to literature data, after implantation of a glaucoma drainage device into the anterior chamber, the speed of endothelial cells density (ECD) loss increases significantly.

Purpose: To study the possibility of performing modified Descemet membrane endothelial keratoplasty (DMEK) with maximum graft diameter, and to assess its short-term effectiveness in the treatment of bullous keratopathy (BK) in the presence of a glaucoma drainage device in the anterior chamber.

Three-quarter DMEK in eyes with glaucoma draining devices to avoid secondary graft failure.

Purpose: To present a case series of a modified three-quarter Descemet's membrane endothelial keratoplasty (3/4-DMEK) technique to treat pseudophakic bullous keratopathy in the presence of a glaucoma drainage device (GDD) tube in the anterior chamber by reducing the risk of donor endothelial damage due to absence of donor endothelial cells overlying the GGD tube area.

Methods: In this prospective case series, four eyes of three patients with stable glaucoma underwent 3/4-DMEK surgery for pseudophakic bullous keratopathy after GDD insertion. The patients were followed up to 24 ± 2.

Two-Dimensional Autofocus Technique Based on Spatial Frequency Domain Fragmentation.

Existing two-dimensional (2-D) autofocus algorithms, exploiting the known structure of 2-D phase error, lack the error estimation accuracy in the case of a low signal-tonoise ratio (SNR) due to the non-exhaustive use of the echo signal. In this paper, we propose a novel 2-D autofocus algorithm, thoroughly utilizing all the available data and therefore achieving superior estimation performance. Via analytical study, we show that the partial derivative of the 2-D error with respect to the azimuth frequency is approximable as a function of single argument, after appropriate change of variable.