[The efficacy of a cultured rabies vaccine studied in guinea pigs preliminarily infected with a fixed rabies virus].

In experiments of curative vaccination, carried out with the use of an experimental model similar to the current practice of treatment with antirabies preparations, the advantages of using tissue-culture rabies vaccine with immunogenic potency equal to 1.3 international units (I. U.

[The interaction of monoclonal antibodies to the structural proteins of the Vnukovo-32 vaccinal virus with other viruses of the rabies group].

The interaction of 7 monoclonal antibodies (MCA) to the nucleocapsid complex and 3 MCA to protein G of the vaccine virus Vnukovo-32 with 33 and 27 members of the rabies virus group, respectively, was studied. The indirect immunofluorescence test showed 7 MCA to the nucleocapsid complex to recognize 4 antigenic determinants (AD). Two MCA recognized the AD common for all the viruses under study.

[The detection of the human immunodeficiency virus antigen in the lymphoid cells of seropositive subjects].

Cells from anti-HIV-positive persons were used in experiments for virus isolation. The RT-activity, viral antigen, nucleic acids, electron microscopic morphology, and infectivity were studied. The data presented allow a conclusion that the virus was isolated.

[The efficacy of a cultured rabies vaccine studied on guinea pigs previously infected with the rabies street virus].

In this work materials on the development of an experimental model for the study of rabies vaccines are presented. The comparative study of different immunization schedules for vaccines with different protective potency has been carried out. Guinea pigs infected with street rabies virus, strain k, were used as an experimental model.