Fibrosarcomatous Dermatofibrosarcoma Protuberans With COL1A1-PDGFB Fusion in a 2-Year-Old Child: A Rare Occurrence With Spectrum of Histopathological Findings and Review of Literature.

Dermatofibrosarcoma protuberans (DFSP) is an intermediate-grade fibroblastic neoplasm commonly seen in young and middle-aged patients and rarely in pediatric patients. Fibrosarcomatous transformation is common in adults but extremely uncommon in children. Here, we present a case of a 2-year-old child who presented with a progressively enlarging subcutaneous mass in the knee.

BIMSSA: enhancing cancer prediction with salp swarm optimization and ensemble machine learning approaches.

Background: Cancer rates are rising rapidly, causing global mortality. According to the World Health Organization (WHO), 9.9 million people died from cancer in 2020.

In-vitro assay studies and molecular docking of functionalized chitosan decorated vanadium pentoxide nano-agents as an antidiabetic drug.

This study aims to enhance the antidiabetic potential of Vanadium pentoxide (VO) by synthesizing chitosan-based nanoparticles (NPs). Chitosan and its derivatives were used to fabricate VO NPs, ensuring enhanced antioxidant and antidiabetic activity. Surface topography was analyzed using atomic force microscopy (AFM), revealing bioactive sites on the NPs with improved electron-transfer capability, as confirmed by cyclic voltammetry (CV).

High-Value Care Education in the USA: Lessons from a National Value Curriculum for Resident and Fellow Physicians.

Purpose: Physicians are estimated to be responsible for more than 50% of national healthcare costs and hold the greatest potential to improve value by orchestrating quality-driven programs to reduce unnecessary practices and variability. A physician's ability to practice cost-conscious care has been linked to their training, underscoring the importance of integrating cost-conscious practice into training.

Methods: The High Value Practice Academic Alliance was formed to help advance the value-improvement work of individual institutions through a national organization.