[Interspecific differences in kemantan pharmacokinetics].

The pharmacokinetics of the new immunostimulant kemantane, adamantane derivative, used in two species of animals (rats and rabbits) and man was studied. There were significant differences in the pharmacokinetics of kemantane and its active metabolite--adamantane-1,4-diol between the species.

[Study of the immunotropic properties of theophylline in lymphocyte culture].

The effect of theophylline on the activation of suppressor cells by histamine was studied in the experiments with mononuclear cells of blood of patients with bronchial asthma and healthy donors. Theophylline (1-5 micrograms/ml) was shown to be able of activating suppressed function of cells of the patients. Incubation of mononuclear cells of the healthy donors with theophylline did not change the process of suppressor formation in vitro.

[Detection of surface immunoglobulins on peripheral lymphocytes in patients with infectious allergic bronchial asthma].

During the examination of 45 patients with infectious allergic asthma and 21 healthy donors the relative number of B-lymphocytes, determined by direct immunofluorescence, was found to be normal in 88% of the patients. In 80% of the patients the relative number of lymphocytes, carrying surface immunoglobulins, exceeded the upper limit of the norm immediately after their isolation, which was due to the presence of exogenous immunoglobulins, partially dissociating from the cell surface after 1-hour incubation at 37 degrees C. The results obtained in this study are of importance in the evaluation of the function of the immune system.