Publications by authors named "P V Donnelly"
Background: Carbonic Anhydrase IX (CAIX) is a zinc metalloenzyme that is over-expressed in many cancers making it a valid target for targeted diagnostic imaging with Positron Emission Tomography (PET). The monoclonal antibody girentuximab binds to CAIX and when radiolabelled with positron-emitting zirconium-89 can be used for diagnostic PET imaging of CAIX positive tumours.
Results: Reaction of desferrioxamine squaramide ethyl ester with girentuximab allowed isolation of a conjugate with desferrioxamine squaramide (DFOSq) covalently attached to girentuximab through stable vinylogous amide linkages to give DFOSq-girentuximab.
Aims: Concerns exist that intravenous (IV) iron might increase the risk of infections. The IRONMAN trial provided an opportunity to investigate whether giving IV ferric derisomaltose (FDI) to patients with heart failure and iron deficiency alters the rate of hospitalization or death due to infections.
Methods And Results: IRONMAN was a randomized trial of IV FDI versus usual care in patients with symptomatic heart failure, left ventricular ejection fraction (LVEF) ≤45%, and transferrin saturation (TSAT) <20% or ferritin <100 μg/L.
Article Synopsis
- * Using data from 1514 patients, the model demonstrated a sensitivity of 73.2% and a high specificity of 97.8%, showing it could correctly identify calcium in coronary artery segments.
- * The model's performance was comparable to human observers, indicating that this automated approach has strong potential for classifying coronary artery calcification efficiently.
Using the coaches voice to improve the representation and experience of females in coaching: a Gaelic games perspective.
Front Sports Act Living
September 2024
Article Synopsis
- Female coaches are really underrepresented in sports globally, and in Ireland only 18.7% of coaches in Gaelic games are women.
- Many women feel undervalued and face challenges like lack of confidence and respect in coaching.
- The research showed that to help more women become coaches, organizations should create supportive environments, offer mentorship, and make coach education more flexible.
We assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of PRSs for 28 diseases and 25 quantitative traits that has been made available on the individuals in UKB, using a unified pipeline for PRS evaluation. We also release a benchmarking software tool to enable like-for-like performance evaluation for different PRSs for the same disease or trait. Extensive benchmarking shows the PRSs in the UKB Release to outperform a broad set of 76 published PRSs.
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