Publications by authors named "P V Bhagwat"
Article Synopsis
- X-linked adrenoleukodystrophy (X-ALD) is a genetic neurodegenerative disorder marked by a mutation in a gene that causes the buildup of very long-chain fatty acids (VLCFAs) and leads to a range of symptoms, from early childhood neuroinflammatory disorders in some males to chronic issues in adult males and female carriers.
- Nearly all male patients show signs of adrenal gland failure, with the age of onset varying and sometimes being the first sign of the disease.
- Studies in fruit flies reveal that knocking down the fly version of the affected gene leads to VLCFA accumulation and other defects, while overexpressing the human version of the gene may inhibit the creation of peroxisomes, suggesting a
Article Synopsis
- The study aims to compare serum immunoglobulin A (IgA) levels among patients with oral submucous fibrosis (OSMF), leukoplakia, and a control group to explore potential links to oral cancer.
- OSMF and leukoplakia are recognized as precursors to oral malignancy, with OSMF showing a notable transformation rate in India; the research employs a specific immunoassay to measure IgA levels in patients.
- Findings suggest that the immunological changes in OSMF and leukoplakia are similar to those in oral cancer, indicating these conditions may serve as indicators of an increased risk for malignancy and highlighting the importance of early detection.
Bioactive peptides (BPs) are short amino acid sequences that that are known to exhibit physiological characteristics such as antioxidant, antimicrobial, antihypertensive and antidiabetic properties, suggesting that they could be exploited as functional foods in the nutraceutical industry. These BPs can be derived from a variety of food sources, including milk, meat, marine, and plant proteins. In the past decade, various methods including in silico, in vitro, and in vivo techniques have been explored to unravel underlying mechanisms of BPs.
View Article and Find Full Text PDFAntibiotic resistance has become one of the most serious threats to human health in recent years. In response to the increasing microbial resistance to the antibiotics currently available, it is imperative to develop new antibiotics or explore new approaches to combat antibiotic resistance. Antimicrobial peptides (AMPs) have shown considerable promise in this regard, as the microbes develop low or no resistance against them.
View Article and Find Full Text PDFBackground: The search for sources of industrial biocatalysts, which are non-pathogenic and can utilise cheap nutrient sources, has been a continuous endeavour in the ~ 7 billion USD enzyme industry. , an endophytic fungal entomopathogen, is non-pathogenic and possesses the potential to secrete various bioproducts while utilising readily available lignocellulosic biomass.
Objective: This study investigated the optimised production of two glycosyl hydrolases, amylase and polygalacturonase, by while utilising readily available agricultural residues.