Publications by authors named "P V Berardo"
Endometriosis presents a pro-inflammatory microenvironment influenced by cytokines, such as interleukin (IL)-8, which expression may be influenced by genetic polymorphisms. Therefore, we aimed to investigate the role of interleukin (IL)-8 rs4073 polymorphism in endometriosis' development and its related symptoms. A case-control study was conducted with 207 women with endometriosis and 193 healthy controls.
View Article and Find Full Text PDFObjective: DROSHA and DICER1 enzymes participate in the main stages of microRNA synthesis. Polymorphisms can influence mRNAs stability and genes expression, and hence affect the binding of miRNAs. Thus, the present study evaluated the association of DROSHA and DICER1 polymorphisms in the development of endometriosis and other diseases.
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- Endometriosis is increasingly recognized as a leading cause of infertility, with genetic factors and the angiogenic process playing significant roles in its development.
- A study involving 283 women with endometriosis and 217 controls revealed a significant association between a specific genetic polymorphism and an increased risk of advanced endometriosis and associated infertility symptoms.
- The findings suggest that the identified polymorphism may influence the severity of endometriosis and its impact on fertility.
Role of cytochrome P450 2C19 polymorphisms and body mass index in endometriosis: A case-control study.
Eur J Obstet Gynecol Reprod Biol
December 2017
Objective: To investigate the contribution of CYP2C19 polymorphisms and body mass index (BMI) in the development of endometriosis.
Study Design: This is a case-control study that includes 356 women (187 cases and 169 controls) recruited from two hospitals in the Brazilian public health system. The genotyping analyses of the CYP2C19*2 and CYP2C19*17 polymorphisms were performed using TaqMan allelic discrimination assays, and the association of the studied polymorphisms with endometriosis was evaluated by multivariate logistic regression.
To evaluate the magnitude of the association of the polymorphisms of the genes and in the development of endometriosis. This is a retrospective case-control study involving 161 women with endometriosis (cases) and 179 controls. The polymorphisms were genotyped by real-time polymerase chain reaction using the TaqMan system.
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