Publications by authors named "P V Benny"
: Vaginal predominance is associated with improved vaginal health and reduced pregnancy complications. Little is known about how dietary quality may improve vaginal microbial composition or about dietary interventions that may promote abundance. To understand the host factors affecting vaginal microbiota during pregnancy in a multi-ethnic cohort in Hawai`i.
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- Arrhythmogenic cardiomyopathy (AC) is a major cause of sudden cardiac arrest in young adults, linked to mutations in the desmoplakin gene, particularly the R2834H mutation which is not well understood.
- 3D models have been created to study how AC-inducing mutations and post-translational modifications affect the structure of desmoplakin’s extreme carboxyterminus tail (DP CT), revealing that PTMs can significantly change its interactions with intermediate filaments.
- Virtual screening of FDA-approved drugs has identified potential treatments for cardiocutaneous diseases, suggesting that drug repurposing could be a viable strategy for addressing AC.
Objective: Bisphenol A and phthalate are known endocrine disruptors and capable of inducing epigenetic changes in the human population. However, their impact on the placenta is less well studied. Our objective was to measure the effect of exposure to bisphenol A and benzyl butyl phthalate in first-trimester HTR8-SVneo and third-trimester 3A-sub E trophoblast cells by profiling the DNA methylation pattern of the imprinting control region of the IGF2 (insulin-like growth factor) and H19 genes.
View Article and Find Full Text PDFBackground: Maternal obesity is a health concern that may predispose newborns to a high risk of medical problems later in life. To understand the intergenerational effect of maternal obesity, we hypothesized that the maternal obesity effect is mediated by epigenetic changes in the CD34+/CD38-/Lin- hematopoietic stem cells (uHSCs) in the offspring. Towards this, we conducted a DNA methylation centric multi-omics study.
View Article and Find Full Text PDFTargeted alpha therapy (TAT) relies on chemical affinity or active targeting using radioimmunoconjugates as strategies to deliver α-emitting radionuclides to cancerous tissue. These strategies can be affected by transmetalation of the parent radionuclide by competing ions in vivo and the bond-breaking recoil energy of decay daughters. The retention of α-emitting radionuclides and the dose delivered to cancer cells are influenced by these processes.
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