Publications by authors named "P V Ajithkumar"
Article Synopsis
- Cutaneous melanoma is increasing globally at a faster rate than other cancers, with metastasis being the leading cause of death in patients, highlighting the need for a better understanding of this process and new treatment options.
- Recent research indicates that epigenetic factors play a significant role in melanoma progression, revealing a mechanism where high DNA methylation can paradoxically activate certain genes instead of silencing them as previously thought.
- The study used a new CRISPR-based system to manipulate DNA methylation in melanoma cells, demonstrating effective changes in gene expression and providing insights into the role of specific genes in the IFN pathway signalling, challenging traditional views on DNA methylation.
Metastatic progression is a complex, multistep process and the leading cause of cancer mortality. There is growing evidence that emphasises the significance of epigenetic modification, specifically DNA methylation and histone modifications, in influencing colorectal (CRC) metastasis. Epigenetic modifications influence the expression of genes involved in various cellular processes, including the pathways associated with metastasis.
View Article and Find Full Text PDFColorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide. The majority of CRC deaths are caused by tumor metastasis, even following treatment. There is strong evidence for epigenetic changes, such as DNA methylation, accompanying CRC metastasis and poorer patient survival.
View Article and Find Full Text PDFPathways for 3-chloro- and 4-chlorobenzoate degradation in Pseudomonas aeruginosa 3mT.
Biodegradation
August 2001
A bacterial isolate, Pseudomonas aeruginosa 3mT exhibited the ability to degrade high concentrations of 3-chlorobenzoate (3-CBA, 8 g l(-1)) and 4-chlorobenzoate (4-CBA 12 g l(-1)) (Ajithkumar 1998). In this study, by delineating the initial biochemical steps involved in the degradation of these compounds, we investigated how this strain can do so well. Resting cells, permeabilised cells as well as cell-free extracts failed to dechlorinate both 3-CBA and 4-CBA under anaerobic conditions, whereas the former two readily degraded both compounds under aerobic conditions.
View Article and Find Full Text PDFMineralization of phenol and its derivatives by Pseudomonas sp. strain CP4.
World J Microbiol Biotechnol
November 1995
A Pseudomonas sp. strain, CP4, was isolated that used phenol up to 1.5 g/l as sole source of carbon and energy.
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