SmartScanPCOS: A feature-driven approach to cutting-edge prediction of Polycystic Ovary Syndrome using Machine Learning and Explainable Artificial Intelligence.

PolyCystic Ovarian Syndrome (PCOS) poses significant challenges to women's reproductive health due to its diagnostic complexity arising from a variety of symptoms, including hirsutism, anovulation, pain, obesity, hyperandrogenism, and oligomenorrhea, necessitating multiple clinical tests. Leveraging Artificial Intelligence (AI) in healthcare offers several benefits that can significantly impact patient care, streamline operations, and improve medical outcomes overall. This study presents an Explainable Artificial Intelligence (XAI)-driven PCOS smart predictor, structured as a hierarchical ensemble consisting of two tiers of Random Forest classifiers following extensive analysis of seven conventional classifiers and two additional stacking ensemble classifiers.

Large Cardamom Extract Enhances Ramipril's Vasoprotective Action in the Aorta by Modulating Endothelial Redox Biology. An Evaluation based on In-silico and In-vitro Research.

Background: The mechanisms that cause a patient's blood pressure to rise are diverse. Controlling blood pressure with monotherapy acting through a single pathway may be unachievable. Combining a clinically used medication with herbal medicine can result in an antihypertensive effect that is two to five times greater than monotherapy.

A Review on Re-Packaging of Bisphosphonates Using Biomaterials.

The need for bone repair and insight into new regeneration therapies as well as improvement of existing regeneration routes is constantly increasing as a direct consequence of the rise in the number of trauma victims, musculoskeletal disorders, and increased life expectancy. Bisphosphonates (BPs) have emerged as a class of drugs with proven efficacy against many bone disorders. The most recent ability of this class of drugs is being explored in its anti-cancer ability.

Renin-angiotensin system modulators in COVID-19 patients with hypertension: friend or foe?

ACE2, a component of the non-classic renin-angiotensin system (RAS), acts as a functional receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) spike protein, which enables the entry of the virus into the host cells. Non-classical ACE2 is one of two types of ACE2 that has a protective effect on vascular and respiratory cells. RAS modulators like angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are among the first-line treatment for hypertensive patients.

Aqueous extract of large cardamom inhibits vascular damage, oxidative stress, and metabolic changes in fructose-fed hypertensive rats.

Purpose: Since metabolic abnormalities such as elevated glucose level and imbalanced lipid profiles increase the risk for hypertension and cause endothelial dysfunction, we evaluated the effect of aqueous extract of large cardamom (AELC) on fructose-induced metabolic hypertension and oxidative stress.

Methods: The male Sprague-Dawley rats were divided into 6 groups with 5 rats in each group, and each group was fed with 10% fructose in drinking water for 8 weeks. Starting from week 5, animals were treated with 50, 100, and 200 mg/kg/day AELC or Losartan (10 mg/kg/day).