Publications by authors named "P Ugocsai"
While cell-free liquid biopsy (cfLB) approaches provide simple and inexpensive disease monitoring, cell-based liquid biopsy (cLB) may enable additional molecular genetic assessment of systemic disease heterogeneity and preclinical model development. We investigated 71 blood samples of 62 patients with various advanced cancer types and subjected enriched circulating tumor cells (CTCs) to organoid culture conditions. CTC-derived tumoroid models were characterized by DNA/RNA sequencing and immunohistochemistry, as well as functional drug testing.
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- Endometrial cancer (EC) is a common malignancy in women, and this study analyzed treatment data for over 34,000 patients in Germany from 2000 to 2020 to assess the effectiveness of various therapies.
- The study found that minimally invasive surgery became more prevalent and was linked to better overall survival compared to traditional open surgery.
- Additionally, advanced risk patients benefited from multimodal treatments, while specific combinations of surgery, radiation, and chemotherapy showed improved survival rates, especially for high-risk and elderly patients.
Purpose: The optimal time to initiation of adjuvant chemotherapy (TTAC) for triple negative breast cancer (TNBC) patients is unclear. This study evaluates the association between TTAC and survival in TNBC patients.
Methods: We conducted a retrospective study using data from a cohort of TNBC patients diagnosed between January 1, 2010 to December 31, 2018, registered in the Tumor Centre Regensburg was conducted.
Article Synopsis
- The study investigates the impact of the time to initiate neoadjuvant chemotherapy (TTNC) on survival rates in patients with early-stage triple negative breast cancer (TNBC).
- A cohort of 270 patients was analyzed, revealing that those who began chemotherapy within 0-42 days post-diagnosis had significantly better 5-year overall survival rates compared to those starting later.
- The findings suggest that delaying treatment beyond 42 days may reduce survival, highlighting the importance of timely intervention in certified breast care centers.
Estrogen receptor-positive breast cancer is a highly prevalent but heterogeneous disease among women. Advanced molecular stratification is required to enable individually most efficient treatments based on relevant prognostic and predictive biomarkers. First objective of our study was the hypothesis-driven discovery of biomarkers involved in tumor progression upon xenotransplantation of Luminal breast cancer into humanized mice.
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