Publications by authors named "P U Blier"
Identification of physiological processes setting thermal tolerance limits is essential to describe adaptive response to temperature changes. We use the North American Daphnia pulex complex, which makes a remarkable model for comparative physiology as it is composed of clones differing in heat tolerance, ploidies and with a wide geographic distribution. The fatty acid composition of 18 diploid and triploid D.
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- The study aimed to investigate the effects of lemborexant (LEM) on individuals with insomnia who also experience mild depression or anxiety symptoms.
- Over a 12-month period, 61 subjects out of 949, who were using medications for depression/anxiety, were evaluated for changes in sleep quality and related measures while being treated with either LEM or a placebo.
- Results showed that while LEM was effective for improving sleep metrics in the subpopulation, the placebo response was stronger, resulting in a smaller effect size for LEM compared to the overall study population, but no new safety concerns were identified.
Assessment of electroencephalographic (EEG) activity in depression has provided insights into neural profiles of the illness. However, there is limited understanding on how symptom severity and risk factors, such as childhood adversity, influence EEG features. Eyes-closed EEG was acquired in N = 28 depressed individuals being treated in a tertiary psychiatric setting.
View Article and Find Full Text PDFThe impact of mutations on the mitochondria deserves specific interest due to the crucial role played by these organelles on numerous cellular functions. This study examines the effects of repeated bottlenecks on mitochondrial function and fitness. Daphnia pulex mutation accumulation lines (MA) lines were maintained for over 120 generations under copper and no copper conditions.
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- Mitochondria play a crucial role in producing ATP necessary for cellular function, particularly in crucial tissues like the heart and brain, and their dysfunction at high temperatures is linked to hyperthermic death.
- As temperatures rise, the efficiency and capacity for ATP synthesis in cardiac and brain mitochondria decline, leading to insufficient ATP for cellular needs and potential organ failure.
- This commentary explores potential causes of mitochondrial failure during hyperthermia, including increased leak respiration and structural changes in the inner mitochondrial membrane that could disrupt proton transport and reduce ATP production.