Publications by authors named "P Turley"
Article Synopsis
- The SBayesRC method combines genome-wide association study (GWAS) summary statistics with functional genomic data to enhance the prediction of complex traits using genetics.* -
- It shows a notable increase in prediction accuracy—14% for European ancestry and up to 34% for cross-ancestry predictions—compared to previous methods, especially SBayesR, which lacks functional annotations.* -
- The study finds that incorporating SNP density and functional information can further improve predictions, with key contributions from evolutionary constrained regions and nonsynonymous SNPs being the most impactful.*
Gestational diabetes mellitus (GDM) is a common metabolic disorder affecting more than 16 million pregnancies annually worldwide. GDM is related to an increased lifetime risk of type 2 diabetes (T2D), with over a third of women developing T2D within 15 years of their GDM diagnosis. The diseases are hypothesized to share a genetic predisposition, but few studies have sought to uncover the genetic underpinnings of GDM.
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