Publications by authors named "P Tsouni"
Article Synopsis
- The study investigates the relationship between infections or vaccinations and the onset of neuralgic amyotrophy (NA), a condition causing nerve pain and weakness.
- Conducted across multiple centers, the research involved matching NA patients with healthy controls while collecting clinical data and biological samples, focusing on prior infections and vaccinations.
- Results showed that 38.6% of NA cases had an identified immune trigger (either an infection or vaccination), with significant associations found between certain viral infections and the severity of the condition.
Aim: Autoimmune nodopathies have specific clinicopathologic features, antibodies directed against nodal proteins (neurofascin 186) or paranodal proteins (neurofascin 155, contactin 1, contactin-associated protein 1 (Caspr1)), and usually have a poor response to first-line therapies for chronic inflammatory demyelinating polyradiculoneuropathy. Anti-Caspr1 nodopathy treated with autologous hematopoietic stem cell transplantation (AHSCT) has not been previously reported.
Methods: We report the first case of an anti-Caspr1 antibody-positive nodopathy refractory to high-intensity immunosuppressive treatment, including rituximab, that responded dramatically to AHSCT.
Background: Acute hepatitis E virus (HEV) infection has recently emerged as a potential trigger for acute dysimmune neuropathies, but prospective controlled studies are lacking.
Aims: To compare the frequency of concomitant acute HEV infection in patients with neuralgic amyotrophy (NA), Guillain-Barré syndrome (GBS), and Bell's palsy with a matched control population.
Methods: Swiss multicenter, prospective, observational, matched case-control study over 3 years (September 2019-October 2022).
Foodborne botulism, a forgotten yet life-threatening disease: a case report.
Eur Rev Med Pharmacol Sci
July 2022
Objective: Botulism is a very rare disease in Switzerland, with less than one case per year, an incidence of 0.01 cases for 100,000 inhabitants. Indeed, over the past ten years, 9 cases have been reported to Public Health registry.
View Article and Find Full Text PDFIn the wake of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, an increasing number of patients with neurological disorders, including Guillain-Barré syndrome (GBS), have been reported following this infection. It remains unclear, however, if these cases are coincidental or not, as most publications were case reports or small regional retrospective cohort studies. The International GBS Outcome Study is an ongoing prospective observational cohort study enrolling patients with GBS within 2 weeks from onset of weakness.
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