Publications by authors named "P Truman"
Article Synopsis
- Parkinson's disease (PD) is a neurodegenerative disorder marked by the loss of dopamine-producing neurons, with lifestyle factors like smoking and coffee consumption potentially lowering its risk.
- Studies suggest that certain components in tobacco and coffee may help protect against PD by inhibiting specific biological processes, reducing neuroinflammation, and activating protective pathways.
- The review aims to enhance our understanding of how these substances may contribute to a reduced incidence of Parkinson's disease and highlights the therapeutic potential of their compounds, although multifunctionality is not necessarily required for these effects.
Rationale: Tobacco monoamine oxidase (MAO) inhibitors have long been suspected of influencing tobacco dependence, but direct evidence of their effects has been difficult to obtain. Recently we have identified two new groups of monoamine oxidase inhibitors, hydroquinones and polyunsaturated fatty acids (linoleic and linolenic acid), abundant in tobacco smoke.
Objectives: To test, in relevant animal models, whether the combined effect of these inhibitors is sufficient to affect addictive responses to nicotine.
Article Synopsis
- E171 (titanium dioxide) is a common food additive found in various products, but its safety is debated due to lacking thorough risk assessments.
- Research indicates that titanium dioxide nanoparticles (TiO NPs) can be toxic to multiple organs, particularly the liver, causing inflammation, cell death, and other significant changes.
- This review aims to shed light on the harmful effects of orally ingested TiO NPs specifically on the liver while addressing the ongoing controversies regarding their toxicity.