Protein expression of CD44 in patients with meningioma tumors: association with clinicopathological parameters and survival.

Objective: Meningiomas are a molecularly ill-defined heterogeneous group of indolent intracranial tumors. Though, WHO grade 1 tumors are histologically benign, sometimes they transform into malignant and may be recurrent which remains always challenging to clinicians. Therefore, the current study sought to discover the clinical relevance of CD44 in meningioma patients.

Open label vancomycin in primary sclerosing cholangitis-inflammatory bowel disease: improved colonic disease activity and associations with changes in host-microbiome-metabolomic signatures.

Background: We conducted a single-arm interventional study, to explore mucosal changes associated with clinical remission under oral vancomycin (OV) treatment, in primary sclerosing cholangitis associated inflammatory bowel disease (PSC-IBD); NCT05376228.

Method: Fifteen patients with PSC and active colitis (median faecal calprotectin 459µg/g; median total Mayo score 5) were treated with OV (125mg QID) for 4 weeks and followed-up for a further 4 weeks of treatment withdrawal (8 weeks, end-of-study). Colonic biopsies were obtained at baseline and week 4.

Isolation of 5-hydroxy-7-methoxy-8-O-β-D-glucopyranosyl-2S-flavanone from a new source, : characterization and anticancer activity.

This study explores the anticancer properties of , a plant indigenous to the Western Ghats of India. We isolated and characterised 5-hydroxy-7-methoxy-8-O-β-D-glucopyranosyl-2S-flavanone from , previously unreported in this plant, using preparative HPLC, NMR, and HRMS techniques. The compound's molecular structure and purity were confirmed, and its biological activity was evaluated on the MDA-MB-231 breast cancer cell line using the MTT assay.

Prospective validation of clino-radio-pathological risk scoring system (CRiSS) for prediction of inguinal lymph-nodes metastasis in squamous cell carcinoma of penis.

Objective: To prospectively validate the diagnostic performance of Clino-radio-pathological Risk Scoring System (CRiSS) for prediction of inguinal lymph-node metastasis (ILNM) in squamous cell carcinoma of penis.

Materials And Methods: A prospective observational study of all patients with SCC penis was conducted between January 1, 2021, and December 31, 2023, at our institute. Data regarding all CRiSS parameters and MRI features of >8mm size and presence of necrosis or irregular outline were recorded, and patients were assigned CRiSS scores and groups.

Unlocking microbial reservoirs for antimicrobial peptides and beyond.

Recently, Santos-Júnior et al. utilized a machine learning approach to identify nearly a million novel antimicrobial peptides (AMPs) from the global microbiome. Here we explore the untapped potential of plant- and soil-associated microbiomes as a source of novel peptides, highlighting their promising applications in advancing agricultural innovation and sustainability.