Publications by authors named "P Trebulle"
Despite abundant genomic and phenotypic data across individuals and environments, the functional impact of most mutations on phenotype remains unclear. Here, we bridge this gap by linking genome to proteome in 800 meiotic progeny from an intercross between two closely related isolates adapted to distinct niches. Modest genetic distance between the parents generated remarkable proteomic diversity that was amplified in the progeny and captured by 6,476 genotype-protein associations, over 1,600 of which we resolved to single variants.
View Article and Find Full Text PDFArticle Synopsis
- - Accessing the genetic diversity of species uncovers hidden traits and helps clarify gene functions, especially in natural isolates of Saccharomyces cerevisiae, where around 20% exhibit aneuploidy, which is contradicted by laboratory findings showing its fitness costs.
- - The research generates a proteomic resource for 796 euploid and aneuploid isolates, revealing that natural aneuploids have better protein dosage compensation compared to lab-generated ones, where many protein subunits show reduced expression.
- - Findings indicate that natural aneuploidy involves enhanced protein turnover and structural changes in the proteasome, suggesting that studying natural genetic diversity can provide valuable insights into the biological mechanisms behind aneupl
Gene expression varies between individuals and corresponds to a key step linking genotypes to phenotypes. However, our knowledge regarding the species-wide genetic control of protein abundance, including its dependency on transcript levels, is very limited. Here, we have determined quantitative proteomes of a large population of 942 diverse natural yeast isolates.
View Article and Find Full Text PDFUnlabelled: Gene expression varies between individuals and corresponds to a key step linking genotypes to phenotypes. However, our knowledge regarding the species-wide genetic control of protein abundance, including its dependency on transcript levels, is very limited. Here, we have determined quantitative proteomes of a large population of 942 diverse natural Saccharomyces cerevisiae yeast isolates.
View Article and Find Full Text PDFArticle Synopsis
- - Metabolism plays a crucial role in aging, with new research on yeast revealing that young cells can exchange metabolites with aging cells, influencing their longevity.
- - The study introduced self-establishing metabolically cooperating communities (SeMeCo) to enhance metabolite exchange, leading to significant lifespan extensions for the cells involved.
- - Key findings showed that cells consuming methionine adjusted their metabolism to be more glycolytic and increased the export of protective metabolites, positively affecting the lifespan of both suppliers and consumers in the community.