Publications by authors named "P Tonin"
Article Synopsis
- HyperCKaemia, or elevated serum creatine kinase (CK), is frequently seen in various myopathies but can also occur in neurological disorders, making diagnosis challenging.
- A case of a 58-year-old man illustrates the complexity, as he had a long history of muscle cramps and high CK levels, and was diagnosed with Charcot-Marie-Tooth disease type 1A through genetic testing.
- Further genetic testing revealed a new variant related to dystrophinopathy, emphasizing the need to thoroughly investigate high CK levels in patients, even those with neurogenic disorders, to ensure proper monitoring for possible myopathy-related complications.
Ischemic preconditioning (PC) induced by a sub-lethal cerebral insult triggers brain tolerance against a subsequent severe injury through diverse mechanisms, including the modulation of the immune system. Tumor necrosis factor (TNF)-α-stimulated gene 6 (TSG-6), a hyaluronate (HA)-binding protein, has recently been involved in the regulation of the neuroimmune response following ischemic stroke. Thus, we aimed at assessing whether the neuroprotective effects of ischemic PC involve the modulation of TSG-6 in a murine model of transient middle cerebral artery occlusion (MCAo).
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- Approximately 57.4 million people worldwide are affected by dementia, with behavioral and psychological symptoms (BPSD), particularly agitation, being prevalent and often challenging to manage.
- The BRAINAID trial tested a nanotechnology device, NanoBEO, on 29 elderly patients (65+) with severe dementia to evaluate its effectiveness in reducing agitation and pain, utilizing a randomized and placebo-controlled design.
- Results indicated that NanoBEO significantly reduced agitation levels and frequency by 28% after 4 weeks, and showed notable pain relief (45.46% improvement) after just 1 week, without requiring additional medications.
Article Synopsis
- The study focuses on diagnosing myofibrillar myopathies (MFM) and distal myopathies (DM), addressing the complexity due to numerous causative genes and overlapping symptoms.
- It involves a retrospective analysis of data from 132 MFM and 298 DM patients collected from various neuromuscular centers, highlighting demographic, genetic, and clinical details.
- Results indicate that 63% of patients had molecular confirmation of their condition, with significant findings including common pathogenic variants and varying ages of onset, as well as notable cardiac and respiratory complications linked to specific genetic variants.
: The COVID-19 pandemic has led to a significant increase in the workloads of healthcare workers (HCWs). The fear of contracting the new virus with the frequent medical consequences has affected their mental health. As a result, they are at high risk of compassion fatigue (CF).
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