Publications by authors named "P Tissieres"
Dysregulation of the renin-angiotensin-aldosterone-system (RAAS) in sepsis is a complex and early phenomenon with a likely significant contribution to organ failure and patient outcomes. A better understanding of the pathophysiology and intricacies of the RAAS in septic shock has led to the use of exogenous angiotensin II as a new therapeutic agent. In this review, we report a multinational and multi-disciplinary expert panel discussion on the role and implications of RAAS modulation in sepsis and the use of exogenous angiotensin II.
View Article and Find Full Text PDFSevere febrile illnesses in children encompass life-threatening organ dysfunction caused by diverse pathogens and other severe inflammatory syndromes. A comparative approach to these illnesses may identify shared and distinct features of host immune dysfunction amenable to immunomodulation. Here, using immunophenotyping with mass cytometry and cell stimulation experiments, we illustrate trajectories of immune dysfunction in 74 children with multi-system inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2, 30 with bacterial infection, 16 with viral infection, 8 with Kawasaki disease, and 42 controls.
View Article and Find Full Text PDFArticle Synopsis
- Sepsis involves a dysregulated immune response driven by interactions between pathogens and the body's damaged cells, activating pattern recognition receptors that lead to organ failure.
- Pancreatic stone protein (PSP) is identified as a significant biomarker for sepsis, with studies indicating it worsens sepsis severity and correlates with increased mortality and organ dysfunction.
- Research suggests PSP may play a role in activating innate immunity through C-type lectin receptors, highlighting its potential as both a diagnostic marker and a therapeutic target in sepsis treatment.
Background And Objectives: Manual blood exchange (MBE) is a leukoreduction therapy for hyperleukocytosis in Bordetella spp.
Infection: We describe the impact of BE on clinical and biological parameters in critically ill children with malignant pertussis.
Materials And Methods: This is a monocentric retrospective review of patients with malignant pertussis infection treated with MBE.
Article Synopsis
- Regulatory T cells (Treg) are crucial for managing immune responses in newborns, especially regarding tolerance to maternal antigens and fighting infections at birth.
- This study, focusing on newborns in West Africa, found that neonates with early-onset sepsis (EOS) had reduced Treg frequency and expression of the Foxp3 marker compared to healthy newborns with prenatal risk factors, indicating a compromised immune profile.
- The findings suggest that specific Treg markers like CTLA-4, PD-1, and CD39 could serve as potential early diagnostic indicators for EOS, as their expression correlates with the severity and outcome of the condition.