Publications by authors named "P Thota"
Primary and secondary antibody deficiencies (PAD and SAD) are amongst the most prevalent immunodeficiency syndromes, often necessitating long-term immune globulin replacement therapy (IRT). Both intravenous immunoglobulin (IVIG) and subcutaneous immunoglobulin (SCIG) have demonstrated efficacy in antibody deficiency. Comparative analyses of these two routes of administration are limited to nurse-administered IVIG and home therapy with self-administered SCIG.
View Article and Find Full Text PDFEosinophilic Esophagitis (EoE) is a chronic inflammatory esophageal disorder, often associated with dysphagia, chest discomfort, and heartburn. There is limited information on persistent esophageal symptoms despite histologic remission (HR). We aimed to assess the prevalence and predictors of persistent esophageal symptoms in adult patients with EoE in HR.
View Article and Find Full Text PDFBackground And Aims: Females with Barrett's esophagus (BE) have a lower risk of neoplastic progression than males, but sufficiently powered risk analyses are lacking. This systematic review and meta-analysis of individual patient data (IPD) aimed to provide more robust evidence on neoplastic progression risk in females.
Methods: We conducted a systematic literature search of 3 electronic databases (Medline, Embase, Google Scholar) from inception until August 2023.
Article Synopsis
- - This systematic review aimed to evaluate how effective vitamin D supplementation is for improving symptoms and reducing relapses in multiple sclerosis (MS) patients, amidst differing opinions on its benefits.
- - A total of 1,345 studies were screened, leading to the inclusion of 16 randomized controlled trials, which generally found that vitamin D significantly increased serum levels compared to placebo and improved MRI results.
- - Despite some positive findings, most studies concluded that vitamin D had no significant impact on relapse rates, fatigue, or other clinical measures, indicating that the effectiveness of vitamin D supplementation for MS symptoms remains unclear.
The pharmaceutical research on natural excipients with diverse physicochemical properties useful in various novel drug delivery systems is a growing interest. The market for natural gums like hupu gum (gum kondagogu) is growing globally, driven by increasing consumer preference for natural and sustainable ingredients. This review covers botanical origin, geographical distribution, chemical constituents, identification tests, toxicology studies and potential applications of hupu gum in novel drug delivery systems.
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