Publications by authors named "P Thoraval"
Article Synopsis
- Researchers studied White Leghorn chicks selected over 18 generations for their tumor regression ability after being infected with Rous sarcoma virus, measuring their tumor profiles through a Tumor Profile Index (TPI).
- The study revealed that tumors developed differently based on the genetic haplotypes and other factors, with distinct growth patterns in progression and regression lines.
- Heritability estimates showed traits related to tumor growth, particularly maximum volume (Vmax), have strong genetic influence, suggesting these traits could guide future breeding selection efforts.
The coding region of the preproinsulin gene has been cloned and partly sequenced in a variety of marine and terrestrial birds (28 species). All genes showed the "ancestral" structure with a large intron-2. The size of intron-2 changed considerably during the evolution of birds (2.
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- The study focuses on using selective breeding in chickens to understand genetic traits linked to disease resistance, specifically against tumors induced by Rous sarcoma virus (RSV).
- Chickens were divided into two groups, one selected for tumor progression and the other for regression, and 18 generations of data were analyzed to evaluate the tumor profile index (TPI) related to tumor size and mortality.
- The research found significant genetic differences between the two groups, with heritability estimates of TPI suggesting a strong genetic basis for resistance to tumors, and preliminary results hinting at a specific genetic association with tumor growth within the progressor line.
The chicken major histocompatibility complex ( MHC) genes are organized into two genetically independent clusters which both possess class I and class IIbeta genes: the classical B complex and the Restriction fragment pattern- Y ( Rfp-Y) complex. In this study, we have examined the role of Rfp-Y genes in transplantation immunity. For this we used three sublines, B19H1, B19H2 and B19H3, derived from a line fixed for B19.
View Article and Find Full Text PDFAims: Lymphoblastoid cell lines derived from Marek's disease virus (MDV) induced tumours have served as models of MDV latency and transformation. They are stable and can be cultured with no detectable MDV genomic alterations upon repeated passaging. An MDV transformed lymphoblastoid T cell line (T9 cell line) has been reported to contain a disrupted MDV BamHI-H fragment and a Rous associated virus insertional activation of the c-myb protooncogene.
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