Publications by authors named "P Thirunavukarasu"
Prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) for the prevention and control of peritoneal metastasis in patients with gastrointestinal malignancies: a systematic review of randomized controlled trials.
EXCLI J
August 2021
Article Synopsis
- Peritoneal metastasis generally leads to a poor prognosis, with untreated survival typically only lasting three to six months.
- A systematic review of randomized controlled trials from 2019 to 2021 assessed the effectiveness of hyperthermic intraperitoneal chemotherapy (HIPEC) in preventing and managing peritoneal metastasis from gastrointestinal cancers, using databases like MEDLINE and EMBASE.
- Results indicated that while HIPEC significantly improved peritoneal recurrence-free survival in patients with gastric cancer, it showed no significant benefits for colorectal cancer patients in preventing peritoneal metastasis.
Appendiceal phlegmon is considered to be sequelae to acute appendicitis which presents as an appendiceal mass composed of the inflamed appendix, the adjacent bowel loops, and the greater omentum. The definitive diagnosis can be obtained by a CT scan of the abdomen. Though conservative management was the most practiced approach, recent studies have shifted the trends towards immediate appendicectomy for the management of appendiceal phlegmon.
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- Crohn's disease (CD) is an inflammatory bowel disease that can cause various complications in the gastrointestinal tract, including anal fistulas, which connect the anal canal to the skin.
- The development of these fistulas is linked to infections from anal crypt glands and significantly affects patients' quality of life, with occurrence rates between 14%-38%.
- Treatment options for fistulas include seton placement for drainage and various biological therapies targeting immune responses, with chronic seton therapy recommended as the primary approach in patients with perianal abscesses.
The diagnosis of synchronous colorectal cancer (CRC) is crucial as the management, including the extent of surgical resection, depends on it. There have been numerous studies on the clinicopathological features of synchronous CRC; however, only a few studies have discussed synchronous cancer treatment. The guidelines to best manage the synchronous and metachronous CRC are limited, especially the most appropriate surgical treatment and chemotherapy based on mutational analysis of mismatch repair genes and the carcinoma sequence model.
View Article and Find Full Text PDFThis study investigated disparities between patients who had local excision versus radical resection for T1 rectal cancer. A retrospective analysis was performed using the National Cancer Data Base, 2004 to 2011. Inclusion criteria consisted of patients with T1, N0 rectal adenocarcinoma that were <3 cm, well or moderately differentiated without perineural invasion.
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