Formulation of Sunscreens for Optimal Efficacy.

Skin exposure to solar radiation can cause many adverse effects. In addition to the sun protection factor (SPF), a parameter associated with Ultraviolet B (UVB) protection, significant evidence emphasized the crucial importance of a well-balanced protection against ultraviolet A (UVA) and for some indications, against high-energy visible light. Synergy between UV filters and filter photostability together with film-forming ingredients such as polymers that ensure the homogeneous distribution of UV filters on the skin are key factors to avoid UVA- and UVB-provoked detrimental effects of solar radiation.

Human Papillomavirus vaccination in general practice in France, three years after the implementation of a targeted vaccine recommendation based on age and sexual history.

In France, vaccination against human papilloma virus (HPV) was recommended in 2007 for all 14-year-old girls as well as "catch-up" vaccination for girls between 15-23 y of age either before or within one year of becoming sexually active. We evaluated the vaccine coverage according to the eligibility for vaccination in a sample of young girls aged 14 to 23 years, who were seen in general practices. A survey was proposed to 706 general practitioners (GPs) and carried out from July to September 2010.

Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome.

Zimmermann-Laband syndrome (ZLS) is a developmental disorder characterized by facial dysmorphism with gingival enlargement, intellectual disability, hypoplasia or aplasia of nails and terminal phalanges, and hypertrichosis. We report that heterozygous missense mutations in KCNH1 account for a considerable proportion of ZLS. KCNH1 encodes the voltage-gated K(+) channel Eag1 (Kv10.