Publications by authors named "P Thebault"
Article Synopsis
- CRISPR-Cas systems are bacterial defenses that help combat viruses and genetic elements, but little is known about their evolution in new environments.* -
- In a study of a poultry pathogen that shifted to a passerine host 30 years ago, researchers observed changes in CRISPR-Cas components, showing adaptations to new viral pressures.* -
- Over time, isolates exhibited a rise in non-functional CRISPR-Cas systems, coinciding with the passerine host's resistance evolution, indicating that this inactivation may have been crucial for bacterial adaptation and increased virulence.*
Biomedical research takes advantage of omic data, such as transcriptomics, to unravel the complexity of diseases. A conventional strategy identifies transcriptomic biomarkers characterized by expression patterns associated with a phenotype by relying on feature selection approaches. Hybrid ensemble feature selection (HEFS) has become increasingly popular as it ensures robustness of the selected features by performing data and functional perturbations.
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- The study focuses on creating polyelectrolyte complexes (PECs) using chitosan and different polysaccharides (CMP and HA), aimed at improving drug delivery systems through nanogels.
- The PECs made from CMP and grafted CMP derivatives showed smaller sizes and better stability than those made with hyaluronic acid, particularly in phosphate buffer saline at physiological pH.
- The PECs demonstrated antioxidant and antibacterial properties, with successful loading and release profiles for drugs like diclofenac and curcumin, illustrating their potential as effective drug carriers.
Intracellular pathogens like Brucella face challenges during the intraphagocytic adaptation phase, where the modulation of gene expression plays an essential role in taking advantage of stressors to persist inside the host cell. This study aims to explore the expression of antisense virB2 RNA strand and related genes under intracellular simulation media. Sense and antisense virB2 RNA strands increased expression when nutrient deprivation and acidification were higher, being starvation more determinative.
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- * In Lausanne, Switzerland, health promotion programs align with 80% of the categories in the S2D grid, showing effective intersectoral collaboration and low redundancy in measures.
- * The findings suggest that SDGs and health promotion are interconnected beyond just Goal 3 (good health and well-being), and the S2D grid can facilitate better collaboration among stakeholders in public health initiatives.