Did the COVID-19 pandemic change the importance of health for life satisfaction? Evidence from France.

COVID-19 has brought health protection to the top of the political agenda in many countries, at the cost of reduced freedoms, social relationships, and economic opportunities. This context may have led individuals to pay more attention to their health and to attach greater importance to it in life satisfaction. This paper examines the possibility of an increase in the correlation between life and health satisfaction after the onset of the pandemic using repeated cross-sectional data in France between 2016 and 2021 and an original jittering strategy to smooth the ordinal variables of life and health satisfaction in regression models of subjective well-being.

TDP43 autoregulation gives rise to dominant negative isoforms that are tightly controlled by transcriptional and post-translational mechanisms.

The nuclear RNA-binding protein TDP43 is integrally involved in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Previous studies uncovered N-terminal TDP43 isoforms that are predominantly cytosolic in localization, prone to aggregation, and enriched in susceptible spinal motor neurons. In healthy cells, however, these shortened (s)TDP43 isoforms are difficult to detect in comparison to full-length (fl)TDP43, raising questions regarding their origin and selective regulation.

Generation of nanobodies with conformational specificity for tau oligomers that recognize tau aggregates from human Alzheimer's disease samples.

Tauopathies are neurodegenerative diseases that involve tau misfolding and aggregation in the brain. These diseases, including Alzheimer's disease (AD), are some of the least understood and most difficult to treat neurodegenerative disorders. Antibodies and antibody fragments that target tau oligomers, which are especially toxic forms of tau, are promising options for immunotherapies and diagnostic tools for tauopathies.