Influence of intensive rearing, continuous and rotational grazing systems of management on parasitic load of lambs.

Aim: A trial was conducted to assess the influence of parasitic load on the lambs reared under the intensive system, continuous grazing, and rotational grazing systems of management.

Materials And Methods: A total of thirty numbers of the undetermined breed of ewe lambs around 4-5 months of age were randomly selected and allotted to three treatment groups: T (intensive system - control), T (rotational grazing), and T (continuous grazing). The T group lambs were raised under a stall-fed system of management, the T group lambs were grazed under rotational grazing strategy in four paddocks of plot-A, while the T group lambs were continuously grazed in plot-B.

Methotrexate treatment provokes apoptosis of proliferating keratinocyte in psoriasis patients.

Psoriasis is a chronic inflammatory skin disease characterized by hyper proliferation of keratinocytes. Recent data show that the epidermis thickening in psoriasis may be related to imbalance of homeostasis caused by abnormal apoptotic process. Maintenance of keratinocyte apoptotic process is very important in psoriasis.

Methotrexate regulates Th-1 response by suppressing caspase-1 and cytokines in psoriasis patients.

Background: Caspase-1 induces the proinflammatory cytokines which appears to be a promising target in Th1-type inflammatory diseases, like psoriasis. We determined the effect of MTX on caspase-1, TNF-α and IL-18 in psoriasis patients.

Methods: We recruited 45 control subjects and 58 psoriasis patients for this study.

Methotrexate normalized keratinocyte activation cycle by overturning abnormal keratins as well as deregulated inflammatory mediators in psoriatic patients.

Background: In psoriatic skin, epidermal keratinocytes undergo deregulated inflammatory response that leads to prolonged expression of inflammatory mediators as well as abnormal keratins. Methotrexate (MTX) is an immunosuppressive agent used as a standard drug to treat severe psoriasis. The aim of the study is to find the pharmacological effect of MTX on abnormal keratin and deregulated inflammatory mediators.