Publications by authors named "P Tawa"
Ischemia is a major limiting factor in Vascularized Composite Allotransplantation (VCA) as irreversible muscular injury can occur after as early as 4-6 h of static cold storage (SCS). Organ preservation technologies have led to the development of storage protocols extending rat liver ex vivo preservation up to 4 days. Development of such a protocol for VCAs has the added challenge of inherent ice nucleating factors of the graft, therefore, this study focused on developing a robust protocol for VCA supercooling.
View Article and Find Full Text PDFVascularized composite allotransplantations are complex procedures with substantial functional impact on patients. Extended preservation of VCAs is of major importance in advancing this field. It would result in improved donor-recipient matching as well as the potential for ex vivo manipulation with gene and cell therapies.
View Article and Find Full Text PDFThe current gold standard for preserving vascularized composite allografts (VCA) is 4°C static cold storage (SCS), albeit muscle vulnerability to ischemia can be described as early as after 2 h of SCS. Alternatively, machine perfusion (MP) is growing in the world of organ preservation. Herein, we investigated the outcomes of oxygenated acellular subnormothermic machine perfusion (SNMP) for 24-h VCA preservation before allotransplantation in a swine model.
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- Vascularized Composite Allografts (VCA) face risks of acute rejection due to full histocompatibility mismatch, relying on different immunosuppression therapies and graft preservation quality.* -
- A systematic review analyzed 211 VCA cases, finding a combination of antithymocyte globulins, mycophenolate mofetil (MMF), tacrolimus, and steroids was most commonly used, with burn patients at a higher risk for acute rejection.* -
- The field of VCA lacks a standardized immunosuppression regimen, indicating a need for more data and comprehensive reporting to better understand the immune responses and optimize treatment strategies.*
Ischemia is a major limiting factor in Vascularized Composite Allotransplantation (VCA) as irreversible muscular injury can occur after as early as 4-6 hours of static cold storage (SCS). Organ preservation technologies have led to the development of storage protocols extending rat liver ex vivo preservation up to 4 days. Development of such a protocol for VCAs has the added challenge of inherent ice nucleating factors of the graft, therefore this study focused on developing a robust protocol for VCA supercooling.
View Article and Find Full Text PDF