New resources for the Drosophila 4th chromosome: FRT101F enabled mitotic clones and Bloom syndrome helicase enabled meiotic recombination.

Genes on the long arm of the Drosophila melanogaster 4th chromosome are difficult to study because the chromosome lacks mitotic and meiotic recombination. Without recombination numerous standard methods of genetic analysis are impossible. Here, we report new resources for the 4th.

An Empirical Study on V2X Enhanced Low-Cost GNSS Cooperative Positioning in Urban Environments.

High-precision and lane selective position estimation is of fundamental importance for prospective advanced driver assistance systems (ADAS) and automated driving functions, as well as for traffic information and management processes in intelligent transportation systems (ITS). User and vehicle positioning is usually based on Global Navigation Satellite System (GNSS), which, as stand-alone positioning, does not meet the necessary requirements in terms of accuracy. Furthermore, the rise of connected driving offers various possibilities to enhance GNSS positioning by applying cooperative positioning (CP) methods.

Adaptive protein divergence of BMP ligands takes place under developmental and evolutionary constraints.

The bone morphogenetic protein (BMP) signaling network, comprising evolutionary conserved BMP2/4/Decapentaplegic (Dpp) and Chordin/Short gastrulation (Sog), is widely utilized for dorsal-ventral (DV) patterning during animal development. A similar network is required for posterior crossvein (PCV) formation in the Drosophila pupal wing. Although both transcriptional and post-transcriptional regulation of co-factors in the network gives rise to tissue-specific and species-specific properties, their mechanisms are incompletely understood.

HLA-frequencies of Austrian umbilical cord blood samples.

We investigated HLA-A, HLA-B, and HLA-DRB1 gene frequencies in 1368 unrelated Austrian umbilical cord blood samples. HLA-C gene frequencies were investigated in a subgroup of 503 samples. HLA typing was performed via sequenced-based typing (SBT).

Cleavage of the Drosophila screw prodomain is critical for a dynamic BMP morphogen gradient in embryogenesis.

Dorsoventral patterning of the Drosophila embryo is regulated by graded distribution of bone morphogenetic proteins (BMPs) composed of two ligands, decapentaplegic (Dpp) a BMP2/4 ortholog and screw (Scw) a BMP5/6/7/8 family member. scw(E1) encodes an unusual allele that was isolated as a dominant enhancer of partial loss-of-function mutations in dpp. However, the molecular mechanisms that underlie this genetic interaction remain to be addressed.