Genomic and transcriptomic profiling of radioresistant prostate and head and neck cancers implicate a BAHD1-dependent modification of DNA damage at the heterochromatin.

Radiotherapy is an integral modality in treating human cancers, but radioresistance remains a clinical challenge due to the involvement of multiple intrinsic cellular and extrinsic tumour microenvironment factors that govern radiosensitivity. To study the intrinsic factors that are associated with cancer radioresistance, we established 4 radioresistant prostate (22Rv1 and DU145) and head and neck cancer (FaDu and HK1) models by irradiating their wild-type parentals to 90 Gy, mimicking the fractionated radiotherapy schema that is often using in the clinic, and performed whole exome and transcriptome sequencing of the radioresistant and wild-type models. Comparative genomic analyses detected the enrichment of mismatch repair mutational signatures (SBS6, 14, 15, 20) across all the cell lines and several non-synonymous single nucleotide variants involved in pro-survival pathways.

Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: A systematic review and meta-analysis.

Background: To analyze the relationship between tumor-infiltrating lymphocytes (TILs) subtypes and infiltration locations and the prognosis of gastric cancer (GC) patients.

Methods: Eligible articles were obtained through systematic retrieval and rigorous screening, collecting study information and extracting hazard ratio (HR), 95 % confidence interval (CI) for pooled analyses of disease-free survival (DFS) and overall survival (OS).

Results: Higher CD4 TILs were correlated with favorable OS (HR=0.

Structure-directing agent mediated synthesis of SnS coupled with Ultraphene as highly stable anode material for sodium-ion battery.

Sodium-ion battery (SIB) with abundant resources has been intensively developed as the efficient energy storage device. Tin disulfide (SnS) is one of the attractive anode materials due to its high capacity and two-dimensional structure. Nevertheless, volume expansion and low conductivity result in the poor rate performance and stability.