Publications by authors named "P T Subramanyam"
Objective: Diagnosis of early onset dementia is critical for initiating management. Although structural MRI is an established procedure for dementia evaluation, early cases may be missed. Neurodegenerative diseases lead to reductions in glucose consumption and grey matter volume loss.
View Article and Find Full Text PDFBrain development is a very complex process that starts within first 20 days of gestation. By the third week, prosencephalon (forebrain), mesencephalon (midbrain), and rhombencephalon (hindbrain) appear. Failure of brain development can occur at any level.
View Article and Find Full Text PDFBackground: PET-Magnetic Resonance (PET-MR) imaging is an upcoming investigative modality with a few installations in Asia and only three in India. PET-Computed Tomography (PET-CT) is an established diagnostic cornerstone for oncological indications but with limited resolution for small lesions due to low soft-tissue contrast and additional radiation exposure.
Objective: Our primary objective was to evaluate the diagnostic performance of simultaneous PET-MR and PET-CT in lesion detection in oncological practice.
The transcription factor SOX2 plays a crucial role in pluripotency during embryogenesis. In this study, we successfully generated porcine induced pluripotent stem cells (piPSC) by transducing porcine fetal fibroblasts with doxycycline-inducible reprogramming lentiviral vectors. To enhance the utility of these piPSCs, we used a CRISPR/Cas9-based homology-directed repair (HDR) system to introduce a nls-zsGreen reporter in-frame and before the stop codon of the SOX2 coding sequence.
View Article and Find Full Text PDFSex Disparities in the Management, Outcomes, and Transfer of Patients Hospitalized for Cardiogenic Shock.
J Soc Cardiovasc Angiogr Interv
March 2024
Article Synopsis
- Previous studies indicated that women experience worse outcomes than men when suffering from cardiogenic shock (CS), especially when treated at less advanced hospitals (spokes) compared to specialized centers (hubs).
- An analysis of over 618,000 hospitalizations revealed that women were less likely to be transferred to hubs, underwent fewer invasive procedures, and had higher in-hospital mortality rates compared to men.
- Findings suggest a need for further research to address the sex disparities in treatment and outcomes for women with cardiogenic shock, as they face greater challenges in receiving optimal care.