Aβ42 biomarker linked to insula, striatum, thalamus and claustrum in dementia with Lewy bodies.

The differential mechanisms between proteinopathies and neurodegeneration in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) remain unclear. To address this issue, we conducted a voxel-based morphometry and cerebrospinal fluid biomarker (α-synuclein, Aβ42, t-Tau and p-Tau) level correlation study in patients with DLB, AD and mixed cases (AD + DLB). Cerebrospinal fluid samples obtained by lumbar puncture and whole-brain T1-weighted images were collected in the AlphaLewyMA cohort.

Adolescents and parents experiencing parental cancer: construction of a nursing intervention model.

Objective: To develop a nursing intervention model for adolescents and parents experiencing parental cancer.

Method: Multimethod research, which integrated five studies: a scoping review and four qualitative studies. Considering the results of these studies, a nursing intervention model was constructed based on two theoretical frameworks, such as the A Model of Children's Adjustment to Parental Cancer, for adolescents, and Neuman Systems Model, for parents, and on a semantic framework, such as Nursing Ontology.

Sensory Changes Following the Lateral Nasal Wall Surgery: A Systematic Review.

The objective of this study was to analyze the sensory changes reported by patients after lateral nasal wall surgery and to assess the prevalence and severity of sensory disturbances, the factors that influence their occurrence, and their impact on patients' quality of life. The methodology adopted in this study was PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis), as well as the PICO (Population, Intervention, Comparison, Outcomes) strategy, which assisted in the development of the study's objectives. Based on the inclusion and exclusion criteria, among all the articles retrieved in the searched databases (PubMed and Google Scholar), we selected 15 articles, considered to be pertinent and relevant to the present investigation.

Stem Cell-Based Therapies for Glaucoma Treatment: A Review Bridging the Gap in Veterinary Patients.

Retinal diseases are characterized by progressive damage to retinal cells, leading to irreversible vision loss. Among these, glaucoma stands out as a multifactorial neurodegenerative disease involving elevated intraocular pressure, retinal ganglion cell apoptosis, and optic nerve damage, ultimately resulting in blindness in both humans and dogs. Stem cell-based therapies have emerged as a promising therapeutic option for such conditions due to their regenerative and neuroprotective potential.