Narcolepsy in early childhood: a case report and a Mini review.

Narcolepsy is a sleep-wake disorder with an onset commonly seen in individuals aged 10-30 years. Due to various reasons, the diagnosis of narcolepsy often experiences a delay of at least ten years. Diagnosing narcolepsy in children is particularly challenging due to atypical symptoms, leading to frequent misdiagnosis or missed diagnoses.

Targeting intracellular cancer proteins with tumor-microenvironment-responsive bispecific nanobody-PROTACs for enhanced therapeutic efficacy.

Proteolysis targeting chimeras (PROTACs) are pivotal in cancer therapy for their ability to degrade specific proteins. However, their non-specificity can lead to systemic toxicity due to protein degradation in normal cells. To address this, we have integrated a nanobody into the PROTACs framework and leveraged the tumor microenvironment to enhance drug specificity.

Host Specificity and Geographic Dispersion Shape Virome Diversity in Rhinolophus Bats.

Rhinolophus bats have been identified as natural reservoirs for viruses with global health implications, including severe acute respiratory syndrome-related coronaviruses (SARSr-CoV) and swine acute diarrhoea syndrome-related coronavirus (SADSr-CoV). In this study, we characterised the individual viromes of 603 bats to systematically investigate the diversity, abundance and geographic distribution of viral communities within R. affinis, R.

The Geometric Series Hypothesis of Leaf Area Distribution and Its Link to the Calculation of the Total Leaf Area per Shoot of 'Aureostriatus'.

Total leaf area per shoot () can reflect the photosynthetic capacity of a shoot. A prior study hypothesized that is proportional to the product of the sum of the individual leaf widths per shoot () and the maximum individual leaf length per shoot (), referred to as the Montgomery-Koyama-Smith equation (MKSE). However, empirical evidence does not support such a proportional relationship hypothesis, as was found to allometrically scale with , i.